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Article

Mechanisms of inactivation of PTCH1 gene in nevoid basal cell carcinoma syndrome: modification of the two-hit hypothesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2010

Pan Shuang, Dong Qing, Sun Li-Sha, Li Tie-Jun

Abstract excerpt

PURPOSE: PTCH1 has been identified as the gene responsible for nevoid basal cell carcinoma syndrome (NBCCS). Keratocystic odontogenic tumors (KCOT) are aggressive jaw lesions that may occur in isolation or in association with NBCCS. The aim of this study was to investigate the genetic and/or epig...

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Source

Identifiers

PMID: 20068110
DOI: 10.1158/1078-0432.CCR-09-2574

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20068110-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mechanisms of inactivation of PTCH1 gene in nevoid basal cell carcinoma syndrome: modification of the two-hit hypothesis.PMID 20068110Read ↗

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PTCH1 gene mutations in Keratocystic odontogenic tumors: a study of 43 Chinese patients and a systematic review.Semantic proximity Read ↗

Biallelic PTCH1 Inactivation Is a Dominant Genomic Change in Sporadic Keratocystic Odontogenic Tumors.Semantic proximity Read ↗

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Novel PTCH1 mutations in patients with keratocystic odontogenic tumors screened for nevoid basal cell carcinoma (NBCC) syndrome.Semantic proximity Read ↗

Biallelic disruption of the PTCH1 gene in multiple basal cell carcinomas in Japanese patients with nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

PTCH1 and SMO gene alterations in keratocystic odontogenic tumors.Semantic proximity Read ↗

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Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor.Semantic proximity Read ↗

A novel mutation of the PTCH1 gene activates the Shh/Gli signaling pathway in a Chinese family with nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

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