Article
Insights into the molecular mechanism of an ABC transporter: conformational changes in the NBD dimer of MJ0796.
The journal of physical chemistry. B - 29 Apr 2010
Oliveira A Sofia F, Baptista António M, Soares Cláudio M
Abstract excerpt
Despite the rapid advances in the study of ABC transporters, many fundamental questions linked to ATP binding/hydrolysis and its relation to the transport cycle remain unanswered. In particular, it is still neither clear nor consensual how the ATP energy is used by the nucleotide binding domains (NBDs) to produce mechanical work and drive the substrate translocation. The major conformational changes in the NBDs...
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