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Article

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter.

Nature communications - 11 Nov 2025

Carrillo Victor Hugo Pérez, Di Cesare Margot, Rose-Sperling Dania, Javed Waqas, Neuweiler Hannes, Marcoux Julien, Orelle Cédric, Jault Jean-Michel, Hellmich Ute A

Abstract excerpt

ATP-binding cassette (ABC) transporters use ATP to transport substrates across membranes. In type IV ABC transporters, which include many multidrug resistance (MDR) pumps, communication between nucleotide-binding domains (NBDs) and transmembrane domains (TMDs) is mediated via large intracellular domains containing 'coupling helices'. However, how ATP hydrolysis and substrate transport are functionally coordinated...

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Topics

Binding Sites
ATP-Binding Cassette Transporters
Adenosine Triphosphate
Bacterial Proteins
Protein Domains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tryptophan

Hydrolysis

Mutation

Models, Molecular

Source

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Identifiers

PMID: 41219214
DOI: 10.1038/s41467-025-65037-y
PMCID: PMC12606247

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