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Article

Release of Entropic Spring Reveals Conformational Coupling Mechanism in the ABC Transporter BtuCD-F.

Biophysical journal - 7 Jun 2016

Prieß Marten, Schäfer Lars V

Abstract excerpt

Substrate translocation by ATP-binding cassette (ABC) transporters involves coupling of ATP binding and hydrolysis in the nucleotide-binding domains (NBDs) to conformational changes in the transmembrane domains. We used molecular dynamics simulations to investigate the atomic-level mechanism of conformational coupling in the ABC transporter BtuCD-F, which imports vitamin B12 across the inner membrane of...

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Identifiers

PMID: 27276259
DOI: 10.1016/j.bpj.2016.04.027
PMCID: PMC4906252

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