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Article

Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease.

Pharmacogenetics and genomics - 1 Apr 2011

Seripa Davide, Bizzarro Alessandra, Pilotto Andrea, D'onofrio Grazia, Vecchione Gennaro, Gallo Antonietta P, Cascavilla Leandro, Paris Francesco, Grandone Elvira, Mecocci Patrizia, Santini Stefano A, Masullo Carlo, Pilotto Alberto

Abstract excerpt

OBJECTIVE: Cytochrome P450 (CYP) 2D6 enzyme is the major responsible for the metabolism of donepezil, an inhibitor of acetyl cholinesterase currently used for the symptomatic treatment of mild-to-moderate Alzheimer's disease (AD). Functional polymorphisms in the CYP2D6 gene may affect enzyme acti...

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PMID: 20859244
DOI: 10.1097/FPC.0b013e32833f984c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20859244-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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