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Article

Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients.

European journal of clinical pharmacology - 1 Sept 2006

Varsaldi Federica, Miglio Gianluca, Scordo Maria Gabriella, Dahl Marja-Liisa, Villa Laura Maria, Biolcati Aldo, Lombardi Grazia

Abstract excerpt

OBJECTIVE: The aims of this study were to evaluate the impact of the CYP2D6 polymorphism on both the steady-state plasma concentrations (Cp) and the clinical outcome of donepezil, a selective acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease (AD). METHODS: Forty-two patients of Caucasian ethnicity affected by probable AD were included in the study. All had been receiving therapy with...

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Identifiers

PMID: 16845507
DOI: 10.1007/s00228-006-0168-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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