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Article

Effects of genetic variability of CYP2D6 on neural substrates of sustained attention during on-task activity.

Translational psychiatry - 6 Oct 2020

Viviani Roberto, Messina Irene, Bosch Julia E, Dommes Lisa, Paul Anna, Schneider Katharina L, Scholl Catharina, Stingl Julia C

Abstract excerpt

The polymorphic drug-metabolizing enzyme CYP2D6, which is responsible for the metabolism of most psychoactive compounds, is expressed not only in the liver, but also in the brain. The effects of its marked genetic polymorphism on the individual capacity to metabolize drugs are well known, but its role in metabolism of neural substrates affecting behavior personality or cognition, suggested by its CNS expression,...

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Identifiers

PMID: 33024081
DOI: 10.1038/s41398-020-01020-z
PMCID: PMC7539151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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