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Article

Genetic variation in CYP2D6 impacts neural activation during cognitive tasks in humans.

NeuroImage - 1 Feb 2012

Stingl Julia C, Esslinger Christine, Tost Heike, Bilek Edda, Kirsch Peter, Ohmle Barbara, Viviani Roberto, Walter Henrik, Rietschel Marcella, Meyer-Lindenberg Andreas

Abstract excerpt

The drug metabolizing cytochrome P450 2D6 enzyme (CYP2D6) is highly expressed in brain and potentially involved in neurotransmitter biotransformation. Here, we report the effect of the CYP2D6 genotype on brain activation during a working memory and an emotional face matching task measured with fMRI. Subjects were taken from an ongoing large scale multicenter imaging genetic study. CYP2D6 genotyping of the alleles...

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Identifiers

PMID: 21835244
DOI: 10.1016/j.neuroimage.2011.07.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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