Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor.

doi:10.1200/JCO.2009.27.6899

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Article

Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2010

Wagner Katharina, Damm Frederik, Göhring Gudrun, Görlich Kerstin, Heuser Michael, Schäfer Irina, Ottmann Oliver, Lübbert Michael, Heit Wolfgang, Kanz Lothar, Schlimok Günter, Raghavachar Aruna A, Fiedler Walter, Kirchner Hartmut H, Brugger Wolfram, Zucknick Manuela, Schlegelberger Brigitte, Heil Gerhard, Ganser Arnold, Krauter Jürgen

Abstract excerpt

PURPOSE: We assessed the prognostic impact of IDH1 R132 mutations and a known single nucleotide polymorphism (SNP) located in the same exon of the IDH1 gene in patients with cytogenetically normal acute myeloid leukemia (CN-AML) in the context of other prognostic markers. PATIENTS AND METHODS: IDH1 exon four was directly sequenced in 275 CN-AML patients from two subsequent AML multicenter treatment trials and 120...

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Identifiers

PMID: 20368538
DOI: 10.1200/JCO.2009.27.6899

Genes

IDH1
FLT3
NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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