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Article

Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation.

Blood advances - 14 Feb 2023

Bill Marius, Jentzsch Madlen, Bischof Lara, Kohlschmidt Jessica, Grimm Juliane, Schmalbrock Laura Katharina, Backhaus Donata, Brauer Dominic, Goldmann Karoline, Franke Georg-Nikolaus, Vucinic Vladan, Niederwieser Dietger, Mims Alice S, Platzbecker Uwe, Eisfeld Ann-Kathrin, Schwind Sebastian

Abstract excerpt

Somatic mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are common in acute myeloid leukemia (AML). The prognostic impact of the presence of IDH mutations may be influenced by the comutational status, the specific location of the mutation (ie, IDH1 R132, IDH2 R140, and IDH2 R172) at diagnosis, and the dynamics of the mutation burden during disease course. Even though many patients with...

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Identifiers

PMID: 35381077
DOI: 10.1182/bloodadvances.2021005789
PMCID: PMC9979713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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