Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.

doi:10.1073/pnas.1706206114

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Article

Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2017

Baker Maggie, Lindell Stephen G, Driscoll Carlos A, Zhou Zhifeng, Yuan Qiaoping, Schwandt Melanie L, Miller-Crews Isaac, Simpson Elizabeth A, Paukner Annika, Ferrari Pier Francesco, Sindhu Ravi Kumar, Razaqyar Muslima, Sommer Wolfgang H, Lopez Juan F, Thompson Robert C, Goldman David, Heilig Markus, Higley J Dee, Suomi Stephen J, Barr Christina S

Abstract excerpt

Adaptations to stress can occur through epigenetic processes and may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n = 13). Focusing on genes with roles in stress response and behavior, we assessed the effects of rearing on H3K4me3...

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PMID: 29078292
DOI: 10.1073/pnas.1706206114
PMCID: PMC5676889

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