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Impact of <i>Fkbp5</i> × Early Life Adversity × Sex in Humanized Mice on Multidimensional Stress Responses and Circadian Rhythmicity

2021-07-08

Abstract excerpt

The cumulative load of genetic predisposition, early life adversity (ELA) and lifestyle shapes the prevalence of psychiatric disorders. Single nucleotide polymorphisms (SNPs) in the human FKBP5 gene were shown to modulate disease risk. To enable investigation of disease-related SNPs in behaviorally relevant context, we generated humanized mouse lines carrying either the risk (AT) or the resiliency (CG) allele of...

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Literature Corpus work
178e52c8-9bd6-5a90-9be6-bf2f88e0917a
DOI
10.1101/2021.07.06.450863
Open publication

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Impact of <i>Fkbp5</i> × Early Life Adversity × Sex in Humanized Mice on Multidimensional Stress Responses and Circadian RhythmicityDOI 10.1101/2021.07.06.450863
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