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Article

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.

Nature - 28 Mar 2002

Gross Cornelius, Zhuang Xiaoxi, Stark Kimberly, Ramboz Sylvie, Oosting Ronald, Kirby Lynn, Santarelli Luca, Beck Sheryl, Hen René

Abstract excerpt

Serotonin is implicated in mood regulation, and drugs acting via the serotonergic system are effective in treating anxiety and depression. Specifically, agonists of the serotonin1A receptor have anxiolytic properties, and knockout mice lacking this receptor show increased anxiety-like behaviour....

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Identifiers

PMID: 11919622
DOI: 10.1038/416396a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11919622-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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