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Detection of ERG11 gene mutation in coding and non-coding region of clinical Candida glabrata (Nakaseomyces glabratu s) isolates from Pakistan

2025-08-27

Abstract excerpt

Abstract Azoles inhibit the cytochrome P450 dependent enzyme lanosterol-14α-demethylase (CYP51) that is encoded by ERG11gene. Azole resistance in Candida species arises through different mechanisms, like mutation in the ERG11gene, ERG11 overexpression, CDR1,2 overexpression, and biofilm formation. We sequenced ERG11 gene to determine mutations in coding and non-coding region of ERG11 in clinical isolates of Candid...

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Literature Corpus work: dc020e69-9c08-5e92-8a42-eba9866024d1
DOI: 10.1099/acmi.0.000952.v5

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