Article
In vitro fluconazole susceptibility of 1,903 clinical isolates of Candida albicans and the identification of ERG11 mutations.
Microbial drug resistance (Larchmont, N.Y.) - 1 Aug 2013
Ying Ying, Zhao Yingjie, Hu Xuefei, Cai Zhenyu, Liu Xin, Jin Guilin, Zhang Jieyu, Zhang Jingyi, Liu Jinhui, Huang Xiaotian
Abstract excerpt
Abstract Fluconazole resistance of Candida albicans has been reported to be the result of one or more specific point mutations in ERG11 gene. In this study, we amplified and sequenced the entire ERG11 coding sequence of 72 isolates of C. albicans to search for possible mutations. Twenty-seven silent mutations and 14 missense mutations were identified. While the mutations K342R and V437I were found as...
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