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Article

Clone competition as a mechanism to reduce tumor formation.

Developmental cell - 20 Dec 2021

Acha-Sagredo Amelia, Malanchi Ilaria, Ciccarelli Francesca D

Abstract excerpt

With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.

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Identifiers

PMID: 34932947
DOI: 10.1016/j.devcel.2021.12.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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