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Article

A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death.

ASN neuro - 31 Mar 2010

Semaan Sheila J, Li Yan, Nickells Robert W

Abstract excerpt

Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J(Bax+/-) mice exhibited complete resistance to nerve damage after 2 weeks (similar to Bax(-/-) mice), but 129B6(Bax+/-) mice exhibited significant cell loss (similar to wild-type mice)....

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Identifiers

PMID: 20360947
DOI: 10.1042/AN20100003
PMCID: PMC2847828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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