Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

G125A single-nucleotide polymorphism in the human BAX promoter affects gene expression.

Oncogene - 17 Mar 2005

Moshynska Oksana, Moshynskyy Igor, Misra Vikram, Saxena Anurag

Abstract excerpt

Earlier we had reported a guanine to adenosine substitution at position 125 (G125A) in the BAX promoter, and its association with higher stage of the disease and failure to achieve complete response to treatment in chronic lymphocytic leukemia (CLL) patients. The aim of this study was to test the hypothesis that G125A leads to a reduction in the transcription of the BAX gene and that this is a direct cause of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Algorithms
Share to bcl-2-Associated X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to Guanine

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Luciferases

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 15688029
DOI: 10.1038/sj.onc.1208377

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

G125A single-nucleotide polymorphism in the human BAX promoter affects gene expression.PMID 15688029Read ↗

Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance.Semantic proximity Read ↗

p53 pathway gene single nucleotide polymorphisms and chronic lymphocytic leukemia.Semantic proximity Read ↗

Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic Leukemia once treatment is initiated.Semantic proximity Read ↗

Molecular detection of the G(-248)A BAX promoter nucleotide change in B cell chronic lymphocytic leukaemia.Semantic proximity Read ↗

BAX gene (-248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil.Semantic proximity Read ↗

A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death.Semantic proximity Read ↗

Influence of BCL2-938C>A and BAX-248G>A promoter polymorphisms in the development of AML: case-control study from South India.Semantic proximity Read ↗

Sequence-based polymorphisms in members of the apoptosis Bcl-2 gene family and their association with hematocrit level.Semantic proximity Read ↗

The Tumor Suppressor Protein p53 Requires a Cofactor to Activate Transcriptionally the Human BAX PromoterSemantic proximity Read ↗

Bax gene G(-248)A promoter polymorphism is associated with increased lifespan of the neutrophils of patients with osteomyelitis.Semantic proximity Read ↗

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce ApoptosisSemantic proximity Read ↗

A base substitution in the promoter associated with the human haptoglobin 2-1 modified phenotype decreases transcriptional activity and responsiveness to interleukin-6 in human hepatoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.