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The Tumor Suppressor Protein p53 Requires a Cofactor to Activate Transcriptionally the Human BAX Promoter

1 May 2001

Abstract excerpt

An important regulator of the proapoptotic BAX is the tumor suppressor protein p53. Unlike the p21 gene, in which p53-dependent transcriptional activation is mediated by a response element containing two consensus p53 half-sites, it previously was reported that activation of the BAX element by p53 requires additional sequences. Here, it is demonstrated that the minimal BAX response element capable of mediating...

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PMID: 11278953
DOI: 10.1074/jbc.m011643200

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The Tumor Suppressor Protein p53 Requires a Cofactor to Activate Transcriptionally the Human BAX PromoterPMID 11278953Read ↗

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