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Article

Silencing of<i>Fem1c<sup>R3</sup></i>Gene Expression in the DBA/2J Mouse Precedes Retinal Ganglion Cell Death and Is Associated with Histone Deacetylase Activity

2 Feb 2012

Abstract excerpt

PURPOSE: Downregulation of normal gene expression in dying retinal ganglion cells has been documented in both acute and chronic models of optic nerve disease. The authors examined the mechanism and timing of this phenomenon in DBA/2J mice, using genetically modified substrains of this inbred line. METHODS: DBA/2J mice, doubly congenic for the Bax mutant allele and the ganglion cell reporter gene Fem1c(Rosa3)...

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Share to Glaucoma and retinal disorders
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PMID: 22297488
DOI: 10.1167/iovs.11-8872

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