Article
Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.
PloS one - 25 Mar 2010
Souslova Veronika, Townsend Paul A, Mann Jelena, van der Loos Chris M, Motterle Anna, D'Acquisto Fulvio, Mann Derek A, Ye Shu
Abstract excerpt
BACKGROUND: Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 gene and that this polymorphism is located within a cis-element that interacts with the transcription factor NFkappaB. In the present study, we sought...
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