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Article

A common Matrix metalloproteinase 8 promoter haplotype enhances the risk for hypertension via diminished interactions with nuclear factor kappa B.

Journal of hypertension - 1 Nov 2022

Maghajothi Sakthisree, Subramanian Lakshmi, Mani Preethi, Singh Mrityunjay, Iyer Dhanya R, Sharma Saurabh, Khullar Madhu, Victor Suma M, Asthana Shailendra, Mullasari Ajit S, Mahapatra Nitish R

Abstract excerpt

OBJECTIVES: Matrix metalloproteinase 8 (MMP8) has a prominent role in collagen turnover in blood vessels and vascular remodeling. The contribution of regulatory single nucleotide polymorphisms in MMP8 to cardiovascular diseases is unclear. We aimed to delineate the influence of MMP8 promoter variations on hypertension. METHODS: A case-control study in unrelated individuals ( n = 2565) was carried out....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36040233
DOI: 10.1097/HJH.0000000000003234

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