Article
An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms.
Human molecular genetics - 15 Dec 2007
Deguara Jean, Burnand Kevin G, Berg Jonathan, Green Peter, Lewis Cathryn M, Chinien Ganesh, Waltham Matthew, Taylor Peter, Stern Rowena F, Stern Rachel F, Solomon Ellen, Smith Alberto
Abstract excerpt
Matrix metalloproteinase 3 (MMP3), is over expressed in the wall of abdominal aortic aneurysms (AAA), while inactivation of the gene expressing this enzyme is associated with reduced aneurysm formation in an experimental model. The 5A allele of the 5A/6A polymorphism in the promoter region of the MMP3 gene is associated with enhanced MMP3 expression. This study aimed to determine whether the presence of the 5A...
Topics
- Aorta
- Aortic Aneurysm, Abdominal
- Arterial Occlusive Diseases
- Cohort Studies
- Female
- Gene Frequency
- Genetic Linkage
- Heterozygote
- Homozygote
- Humans