Article
<i>Salmonella</i> -mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells
1 Apr 2010
Abstract excerpt
A fundamental challenge in gene therapy is to develop approaches for delivering nucleic acid-based gene interfering agents, such as small interfering RNAs and ribozymes, to the appropriate cells in a way that is tissue/cell specific, efficient, and safe. Using human cytomegalovirus (HCMV) infection of differentiated macrophages as the model, we showed that Salmonella can efficiently deliver RNase P-based ribozyme...
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