Article

An optimized live bacterial delivery platform for the production and delivery of therapeutic nucleic acids and proteins

2021-10-17

Abstract excerpt

There is an unmet need for delivery platforms that realize the full potential of next-generation therapeutic and vaccine technologies, especially those that require intracellular delivery of nucleic acids. The in vivo usefulness of the current state-of-the-art delivery systems is limited by numerous intrinsic weaknesses, including lack of targeting specificity, inefficient entry and endosomal escape into target ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2e86059-e9bd-5912-ba0b-6a59e8e16267
DOI: 10.1101/2021.10.17.464697

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An optimized live bacterial delivery platform for the production and delivery of therapeutic nucleic acids and proteinsDOI 10.1101/2021.10.17.464697Read

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome EditingSemantic proximity Read

Trojan Horse-Like Vehicles for CRISPR-Cas Delivery: Engineering Extracellular Vesicles and Virus-Like Particles for Precision Gene Editing in Cystic FibrosisSemantic proximity Read

Engineering Human ARMMs as Therapeutic Non-Viral Vehicles for <i>in vivo</i> Delivery of Genome Editing PayloadsSemantic proximity Read

An exosome-based gene delivery platform for cell-specific CRISPR/Cas9 genome editingSemantic proximity Read

Unlocking the potential of RNA-based therapeutics in the lung: current status and future directionsSemantic proximity Read

CRISPR delivery with extracellular vesicles: Promises and challengesSemantic proximity Read

Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivoSemantic proximity Read

Bacterial extracellular vesicles as a tunable platform for vaginal drug deliverySemantic proximity Read

<i>In situ</i> targeted mutagenesis of gut bacteriaSemantic proximity Read

Generation of Cellular Biofactories for Scalable Production of Surface-Engineered Extracellular Vesicles via CRISPR Genome EditingSemantic proximity Read

Rational Design of Virus-like Particles for NanomedicineSemantic proximity Read

Targeted Delivery of Nucleic Acid and Protein Cargos into Primary Human Hematopoietic Stem Cells Using Bacteriophage T4Semantic proximity Read