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Article

Turning self-destructing <i>Salmonella</i> into a universal DNA vaccine delivery platform

5 Nov 2012

Abstract excerpt

We previously developed a biological containment system using recombinant Salmonella Typhimurium strains that are attenuated yet capable of synthesizing protective antigens. The regulated delayed attenuation and programmed self-destructing features designed into these S. Typhimurium strains enable them to efficiently colonize host tissues and allow release of the bacterial cell contents after lysis. To turn such...

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PMID: 23129620
DOI: 10.1073/pnas.1217554109

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