Targeted Delivery of Nucleic Acid and Protein Cargos into Primary Human Hematopoietic Stem Cells Using Bacteriophage T4

Abstract excerpt

Here, we report, for the first time, delivery of mRNA and/or protein payloads into primary adult human hematopoietic stem cells (HSCs) using a bacteriophage-derived nanoparticle vector. We have been developing a new category of bacteriophage T4-engineered nanoparticles, termed “artificial viral vectors” (AVVs), for delivering therapeutic nucleic acid and protein complexes into human cells. Using a defined in vitr...

Topics

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• Advanced biosensing and bioanalysis techniques
• Bacteriophages and microbial interactions
• Cancer Research and Treatments
• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Monoclonal and Polyclonal Antibodies Research
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

a34ad6cf-221a-5597-8a14-5a16ad59347d

DOI

10.64898/2026.01.28.702426