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Article

Yeast-mediated mRNA delivery polarizes immuno-suppressive macrophages towards an immuno-stimulatory phenotype.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V - 1 Aug 2017

Seif Michelle, Hoppstädter Jessica, Breinig Frank, Kiemer Alexandra K

Abstract excerpt

Macrophages have increasingly gained interest as a therapeutic target since they represent an integral component of the tumor microenvironment. In fact, M2 macrophage accumulation in solid tumors is associated with poor prognosis and therapy failure. Therefore, reprogramming M2 macrophages towards an M1 phenotype with anti-tumor activity by gene therapy represents a promising therapeutic approach. Herein, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28323110
DOI: 10.1016/j.ejpb.2017.03.008

Genes

MYD88
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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