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Article

TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque, negatively modulates TRIM5α activity.

Biochemical and biophysical research communications - 4 Apr 2014

Na Lei, Tang Yan-Dong, Liu Jian-Dong, Yu Chang-Qing, Sun Liu-Ke, Lin Yue-Zhi, Wang Xue-Feng, Wang Xiaojun, Zhou Jian-Hua

Abstract excerpt

The existence of innate, host-specific restriction factors is a major obstacle to the development of nonhuman primate models for AIDS studies, and TRIM5α is one of the most important of these restriction factors. In recent years, a TRIM5 chimeric gene that was retrotransposed by a cyclophilin A (CypA) cDNA was identified in certain macaque species. The TRIM5α-CypA fusion protein, TRIMCyp, which was expressed in...

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PMID: 24613845
DOI: 10.1016/j.bbrc.2014.02.132

Genes

TRIM5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque, negatively modulates TRIM5α activity.PMID 24613845Read ↗

Evolution of a TRIM5-CypA splice isoform in old world monkeys.Semantic proximity Read ↗

Independent evolution of an antiviral TRIMCyp in rhesus macaquesSemantic proximity Read ↗

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A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infectionSemantic proximity Read ↗

Rhesus monkey TRIM5α has distinct HIV-1 restriction activity among different mammalian cell lines.Semantic proximity Read ↗

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TRIM5α and Species Tropism of HIV/SIVSemantic proximity Read ↗

TRIMCyp expression in Old World primates <i>Macaca nemestrina</i> and <i>Macaca fascicularis</i>Semantic proximity Read ↗

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