MMPs - Role in Cardiovascular Development and Disease

Abstract excerpt

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes important in the degradation and turnover of extracellular matrix (ECM) components. MMPs and their inhibitors play major roles not only in ECM degradation but also in mediating cell-cell adhesion, cell migration and invasion, cell proliferation and apoptosis, tissue remodeling, and growth factor and cytokine signaling. There is a vast amount of...

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