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Article

Matrix metalloproteinases: a therapeutic target in cardiovascular disease.

Current pharmaceutical design - 1 Jan 2003

Sierevogel M J, Pasterkamp G, de Kleijn D P V, Strauss B H

Abstract excerpt

Cardiovascular disease is the leading cause of death in Western society. Extracellular matrix turnover is important in many cardiovascular pathologies, such as arterial remodeling, plaque rupture, restenosis, aneurysm formation and heart failure. Matrix metalloproteinases (MMPs) belong to a group of zinc and calcium dependent proteases and cause breakdown of the extracellular matrix. MMP inhibitors have been...

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Identifiers

PMID: 12678855
DOI: 10.2174/1381612033455099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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