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Article

Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice.

Cardiovascular research - 1 Dec 2012

Chiao Ying Ann, Ramirez Trevi A, Zamilpa Rogelio, Okoronkwo S Michelle, Dai Qiuxia, Zhang Jianhua, Jin Yu-Fang, Lindsey Merry L

Abstract excerpt

AIMS: Age-related diastolic dysfunction has been attributed to an increased passive stiffness, which is regulated by extracellular matrix (ECM). We recently showed that matrix metalloproteinase (MMP)-9, an ECM mediator, increases in the left ventricle (LV) with age. The aim of this study, accordingly, was to determine the role of MMP-9 in cardiac ageing. METHODS AND RESULTS: We compared LV function in young (6-9...

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Identifiers

PMID: 22918978
DOI: 10.1093/cvr/cvs275
PMCID: PMC3500048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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