Article
Quantitative trait locus on chromosome X affects bone loss after maturation in mice.
Journal of bone and mineral metabolism - 1 Sept 2010
Okudaira Shuzo, Shimizu Motoyuki, Otsuki Bungo, Nakanishi Rika, Ohta Akira, Higuchi Keiichi, Hosokawa Masanori, Tsuboyama Tadao, Nakamura Takashi
Abstract excerpt
Genetic programming is known to affect the peak bone mass and bone loss after maturation. However, little is known about how polymorphic genes on chromosome X (Chr X) modulate bone loss after maturation. We previously reported a quantitative trait locus (QTL) on Chr X, designated Pbd3, which had a suggestive linkage to bone mass, in male SAMP2 and SAMP6 mice. In this study, we aimed to clarify the effects of Pbd3...
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