Article
Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 1999
Shimizu M, Higuchi K, Bennett B, Xia C, Tsuboyama T, Kasai S, Chiba T, Fujisawa H, Kogishi K, Kitado H, Kimoto M, Takeda N, Matsushita M, Okumura H, Serikawa T, Nakamura T, Johnson T E, Hosokawa M
Abstract excerpt
The whole genome scan for quantitative trait loci (QTLs) specifying peak bone mass was performed with the F2 intercrosses of SAMP6, an established murine model of senile osteoporosis, exhibiting a significantly lower peak bone mass, and SAMP2, exhibiting a higher peak bone mass. Cortical thicknes...
Topics
- Animals
- Bone Density
- Chromosome Mapping
- Chromosomes
- Female
- Femur
- Genotype
- Male
- Mice
- Mice, Mutant Strains
- Osteoporosis
- Phenotype
- Quantitative Trait, Heritable
- Sex Chromosomes