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Article

Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22.

Human molecular genetics - 1 Nov 2005

Parsons Claire A, Mroczkowski H Joel, McGuigan Fiona E A, Albagha Omar M E, Manolagas Stavros, Reid David M, Ralston Stuart H, Shmookler Reis Robert J

Abstract excerpt

Bone mineral density (BMD) is a complex trait with a strong genetic component and an important predictor of osteoporotic fracture risk. Here we report the use of a cross-species strategy to identify genes that regulate BMD, proceeding from quantitative trait mapping in mice to association mapping of the syntenic region in the human genome. We identified a quantitative trait locus (QTL) on the mouse X-chromosome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16183656
DOI: 10.1093/hmg/ddi346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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