Article
A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2002
Shimizu Motoyuki, Higuchi Keiichi, Kasai Soichiro, Tsuboyama Tadao, Matsushita Mutsumi, Matsumura Takuro, Okudaira Shuzo, Mori Masayuki, Koizumi Akio, Nakamura Takashi, Hosokawa Masanori
Abstract excerpt
Previously, we identified two significant quantitative trait loci (QTLs) specifying the peak relative bone mass (bone mass corrected for bone size) on chromosomes (Chrs) 11 and 13 by interval mapping in two mouse strains, SAMP2 and SAMP6. The latter strain is an established murine model of senile osteoporosis and exhibits a significantly lower peak relative bone mass than SAMP2 mice. We recently designated the...
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