Article
Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit.
Proceedings of the National Academy of Sciences of the United States of America - 18 May 2004
Thomas Celestine J, Du Xinlin, Li PiLong, Wang Ying, Ross Elliott M, Sprang Stephen R
Abstract excerpt
Heterotrimeric G protein alpha (G alpha) subunits possess intrinsic GTPase activity that leads to functional deactivation with a rate constant of approximately 2 min(-1) at 30 degrees C. GTP hydrolysis causes conformational changes in three regions of G alpha, including Switch I and Switch II. Mutation of G202-->A in Switch II of G alpha(i1) accelerates the rates of both GTP hydrolysis and conformational change,...
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