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Article

Alterations in the p53-SOCS2 axis contribute to tumor growth in colon cancer

1 Apr 2018

Abstract excerpt

Altered expression of suppressor of cytokine signaling (SOCS) is found in various tumors. However, regulation of SOCS2 by upstream molecules has yet to be clearly elucidated, particularly in tumor cells. SCOCS2 expression was examined in tumor cells transfected with an inducible p53 expression system. The impact of SOCS2 on cell proliferation was measured with in vitro assays. Inhibition of tumorigenicity by...

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PMID: 29622769
DOI: 10.1038/s12276-017-0001-1

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