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Article

Tumour-promoting role of SOCS1 in colorectal cancer cells

22 Sept 2015

Abstract excerpt

The SOCS1 (Suppressor Of Cytokine Signalling 1) protein is considered a tumour suppressor. Notably, the SOCS1 gene is frequently silenced in cancer by hypermethylation of its promoter. Besides blocking inflammation, SOCS1 tumour suppressor activity involves Met receptor inhibition and enhancement of p53 tumour suppressor activity. However, the role of SOCS1 in colorectal cancer (CRC) remains understudied and...

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PMID: 26391193
DOI: 10.1038/srep14301

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