Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of GNAS and TSHR genes in subclinical toxic multinodular goiter.

The Annals of otology, rhinology, and laryngology - 1 Feb 2010

Liu Chunbo, Wu Changjun, Wang Fengjun, Zhou Min

Abstract excerpt

OBJECTIVES: This study aimed to detect the mutations of the GNAS and TSHR genes in subclinical toxic multinodular goiter (sTMG) and to evaluate the relationship between these mutations and sTMG. METHODS: Forty-four patients with sTMG and 20 matched controls (multinodular goiter) were recruited into this study. All of the patients underwent subtotal thyroidectomy. Gene mutations were analyzed by direct DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy, Fine-Needle
Share to Chromogranins
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Goiter, Nodular

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Polymerase Chain Reaction

Share to Receptors, Thyrotropin

Share to Thyroid Gland

Source

Identifiers

PMID: 20336923
DOI: 10.1177/000348941011900209

Genes

TSHR
GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of GNAS and TSHR genes in subclinical toxic multinodular goiter.PMID 20336923Read ↗

United detection GNAS and TSHR mutations in subclinical toxic multinodular goiter.Semantic proximity Read ↗

Molecular pathogenesis of euthyroid and toxic multinodular goiter.Semantic proximity Read ↗

Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.Semantic proximity Read ↗

Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?Semantic proximity Read ↗

Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters.Semantic proximity Read ↗

Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas.Semantic proximity Read ↗

Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.Semantic proximity Read ↗

Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.Semantic proximity Read ↗

Pathogenesis of toxic thyroid adenomas and nodules: relevance of activating mutations in the TSH-receptor and Gs-alpha gene, the possible role of iodine deficiency and secondary and TSH-independent molecular mechanisms.Semantic proximity Read ↗

Nonautoimmune Hyperthyroidism Caused by a Somatic Mosaic GNAS Mutation Involving Part of the Thyroid Gland.Semantic proximity Read ↗

Lack of reported mutations in a Japanese case of toxic multinodular goiter.Semantic proximity Read ↗

Activating thyrotropin receptor mutations in histologically heterogeneous hyperfunctioning nodules of multinodular goiter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.