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Article

[Molecular-targeted therapies for spinal and bulbar muscular atrophy].

Rinsho shinkeigaku = Clinical neurology - 1 Nov 2009

Katsuno Masahisa, Banno Haruhiko, Suzuki Keisuke, Adachi Hiroaki, Tanaka Fumiaki, Sobue Gen

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine-mediated lower motor neuron disease characterized by slowly progressive muscle weakness and atrophy. The cause of this disease is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine tract, within the first exon of the androgen receptor (AR) gene. SBMA exclusively occurs in adult males, whereas both heterozygous and homozygous...

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Identifiers

PMID: 20030248
DOI: 10.5692/clinicalneurol.49.917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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