Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.

Neurobiology of aging - 1 Nov 2013

Rusmini Paola, Crippa Valeria, Giorgetti Elisa, Boncoraglio Alessandra, Cristofani Riccardo, Carra Serena, Poletti Angelo

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfolds, forming cytoplasmic and nuclear aggregates in the affected neurons. Neurotoxicity only appears to be associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Cysteine Proteinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leupeptins

Share to Motor Neurons

Share to Receptors, Androgen

Share to Sequestosome-1 Protein

Share to Testosterone

Share to Trehalose

Source

Open in PubMed Open full text

Identifiers

PMID: 23810450
DOI: 10.1016/j.neurobiolaging.2013.05.026
PMCID: PMC3748343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.PMID 23810450Read ↗

Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular AtrophySemantic proximity Read ↗

Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular AtrophySemantic proximity Read ↗

17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy.Semantic proximity Read ↗

p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.Semantic proximity Read ↗

Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Aggregation and proteasome: the case of elongated polyglutamine aggregation in spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophySemantic proximity Read ↗

[Molecular-targeted therapies for spinal and bulbar muscular atrophy].Semantic proximity Read ↗

Molecular Mechanisms and Therapeutics for SBMA/Kennedy's DiseaseSemantic proximity Read ↗

Human Adipose-Derived Mesenchymal Stem Cells as a New Model of Spinal and Bulbar Muscular AtrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.