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Article

Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice.

Human molecular genetics - 15 Jan 2001

Abel A, Walcott J, Woods J, Duda J, Merry D E

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by the expansion of a polyglutamine tract within the androgen receptor. This disease is unusual among the polyglutamine diseases in that it involves lower motor and sensory neurons, with relative sparing of other brain structures. We describe the development of transgenic mice, created with a truncated, highly expanded androgen receptor...

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Identifiers

PMID: 11152658
DOI: 10.1093/hmg/10.2.107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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