p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

doi:10.1523/JNEUROSCI.3021-12.2013

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Article

p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2013

Doi Hideki, Adachi Hiroaki, Katsuno Masahisa, Minamiyama Makoto, Matsumoto Shinjiro, Kondo Naohide, Miyazaki Yu, Iida Madoka, Tohnai Genki, Qiang Qiang, Tanaka Fumiaki, Yanagawa Toru, Warabi Eiji, Ishii Tetsuro, Sobue Gen

Abstract excerpt

Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders that are caused by the expansion of trinucleotide CAG repeats in the causative genes. Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease that is caused by the expansion of a polyQ tract within the androgen receptor (AR). p62 is a ubiquitin- and light-chain 3-binding protein that is known to regulate the...

Topics

Aged
Animals
Autophagy
Disease Models, Animal
Female
Gene Expression Regulation
Humans
Inclusion Bodies
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Transgenic

Middle Aged

Muscular Disorders, Atrophic

Mutation

Nervous System Diseases

PC12 Cells

Peptides

Source

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Identifiers

PMID: 23637164
DOI: 10.1523/JNEUROSCI.3021-12.2013
PMCID: PMC6618982

Genes

SQSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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