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Article

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

Brain : a journal of neurology - 1 Mar 2005

Adachi Hiroaki, Katsuno Masahisa, Minamiyama Makoto, Waza Masahiro, Sang Chen, Nakagomi Yuji, Kobayashi Yasushi, Tanaka Fumiaki, Doyu Manabu, Inukai Akira, Yoshida Mari, Hashizume Yoshio, Sobue Gen

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is an inherited adult onset motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR), affecting only males. The characteristic pathological finding is nuclear inclusions (NIs) consisting of mutant AR with an expanded polyQ in residual motor neurons, and in certain visceral organs. We immunohistochemically examined 11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15659427
DOI: 10.1093/brain/awh381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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