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Article

Competitive Fitness of Influenza B Viruses Possessing E119A and H274Y Neuraminidase Inhibitor Resistance-Associated Substitutions in Ferrets.

PloS one - 1 Jan 2016

Pascua Philippe Noriel Q, Marathe Bindumadhav M, Burnham Andrew J, Vogel Peter, Webby Richard J, Webster Robert G, Govorkova Elena A

Abstract excerpt

Neuraminidase (NA) inhibitors (NAIs) are the only antiviral drugs recommended for influenza treatment and prophylaxis. Although NAI-resistant influenza B viruses that could pose a threat to public health have been reported in the field, their fitness is poorly understood. We evaluated in ferrets the pathogenicity and relative fitness of reverse genetics (rg)-generated influenza B/Yamanashi/166/1998-like viruses...

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Identifiers

PMID: 27466813
DOI: 10.1371/journal.pone.0159847
PMCID: PMC4965113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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