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Article

Factors affecting relative fitness measurements in pairwise competition assays of human immunodeficiency viruses.

Journal of virological methods - 1 Dec 2013

Lanxon-Cookson Erinn C, Swain J Victor, Manocheewa Siriphan, Smith Robert A, Maust Brandon, Kim Moon, Westfall Dylan, Rolland Morgane, Mullins James I

Abstract excerpt

Cell culture growth competition assays of human immunodeficiency virus type 1 (HIV-1) are used to estimate viral fitness and quantify the impact of mutations conferring drug resistance and immunological escape. A comprehensive study of growth competition assays was conducted and identified experimental parameters that can impact measurements of relative fitness including multiplicity of infection, viral input...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23933395
DOI: 10.1016/j.jviromet.2013.07.062
PMCID: PMC3825816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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