Article
Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.
Immunity - 1 Feb 2001
Takahashi Y, Ohta H, Takemori T
Abstract excerpt
In T cell-dependent immune responses, high-affinity B cells are selected and differentiate into memory cells; however, the mechanism behind this process remains largely unknown. Here, we report that the selection of high-affinity B cells within germinal centers (GCs) is impaired in Fas-deficient lpr mice in the primary response, probably owing to inefficient negative selection. The memory compartment in control...
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