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Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2006

Okamoto Kazuo, Fujisawa Jun-ichi, Reth Michael, Yonehara Shin

Abstract excerpt

Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia and induces autoimmune disease. Previous analyses of tax transgenic mice suggested that protection of peripheral T-cells from Fas-mediated apoptosis by virus-encoded oncoprotein Tax was relevant to the onset of HTLV-I-induced diseases. Here, we show the high level expression of cellular FLICE/caspase-8-inhibitory protein...

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Source

Identifiers

PMID: 16436054
DOI: 10.1111/j.1365-2443.2006.00927.x

Genes

ATF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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