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Article

Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Mar 2010

Wong Yu-Hui, Lu Ai-Chu, Wang Yu-Chiuan, Cheng Hsu-Chen, Chang Celia, Chen Po-Hao, Yu Jenn-Yah, Fann Ming-Ji

Abstract excerpt

Many Ig superfamily members are expressed in the developing nervous system, but the functions of these molecules during neurogenesis are not all clear. Here, we explore the expression and function of one of members of this superfamily, protogenin (PRTG), in the developing nervous system. Expression of PRTG protein is strong in the neural tube of mouse embryos between embryonic days 7.75 and 9.5 but disappears...

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Identifiers

PMID: 20335479
DOI: 10.1523/JNEUROSCI.0473-10.2010
PMCID: PMC6634505

Genes

PRTG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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